Protein tạo hình xương 2 Mẫu hình biểu hiện RNA Mẫu hình biểu hiện RNAThêm nguồn tham khảo về sự biểu hiện Quá trình sinh học • skeletal system development• positive regulation of Wnt signaling pathway by BMP signaling pathway• positive regulation of protein phosphorylation• mesenchyme development• negative regulation of cell cycle• odontogenesis of dentin-containing tooth• telencephalon regionalization• protein phosphorylation• atrioventricular valve morphogenesis• proteoglycan metabolic process• mesenchymal cell differentiation• pericardium development• positive regulation of ERK1 and ERK2 cascade• BMP signaling pathway involved in heart induction• animal organ morphogenesis• inner ear development• cardiocyte differentiation• negative regulation of canonical Wnt signaling pathway• negative regulation of cell proliferation• positive regulation of p38MAPK cascade• pathway-restricted SMAD protein phosphorylation• cell fate commitment• regulation of transcription, DNA-templated• SMAD protein signal transduction• ossification• in utero embryonic development• mesenchymal cell proliferation involved in ureteric bud development• regulation of odontogenesis of dentin-containing tooth• positive regulation of transcription, DNA-templated• positive regulation of Wnt signaling pathway• heart development• telencephalon development• branching involved in ureteric bud morphogenesis• negative regulation of Wnt signaling pathway involved in heart development• cartilage development• bone mineralization involved in bone maturation• positive regulation of cartilage development• positive regulation of neuron differentiation• positive regulation of cell differentiation• thyroid-stimulating hormone-secreting cell differentiation• inflammatory response• positive regulation of fat cell differentiation• negative regulation of steroid biosynthetic process• positive regulation of MAPK cascade• Notch signaling pathway• bone mineralization• Biệt hóa tế bào• chondrocyte differentiation• corticotropin hormone secreting cell differentiation• positive regulation of astrocyte differentiation• positive regulation of bone mineralization• cellular response to organic cyclic compound• positive regulation of ossification• negative regulation of transcription from RNA polymerase II promoter• positive regulation of epithelial to mesenchymal transition• positive regulation of phosphatase activity• negative regulation of calcium-independent cell-cell adhesion• positive regulation of osteoblast differentiation• activation of MAPK activity• protein destabilization• embryonic heart tube anterior/posterior pattern specification• osteoblast differentiation• epithelial to mesenchymal transition• positive regulation of protein binding• negative regulation of transcription, DNA-templated• positive regulation of odontogenesis• positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus• negative regulation of aldosterone biosynthetic process• positive regulation of osteoblast proliferation• response to hypoxia• positive regulation of endothelial cell proliferation• positive regulation of cell migration• negative regulation of cortisol biosynthetic process• cell-cell signaling• positive regulation of pathway-restricted SMAD protein phosphorylation• cellular response to growth factor stimulus• cellular response to BMP stimulus• cardiac muscle tissue morphogenesis• endocardial cushion morphogenesis• multicellular organism development• negative regulation of cardiac muscle cell differentiation• positive regulation of apoptotic process• negative regulation of insulin-like growth factor receptor signaling pathway• oxidation-reduction process• positive regulation of transcription from RNA polymerase II promoter• cardiac epithelial to mesenchymal transition• positive regulation of pri-miRNA transcription from RNA polymerase II promoter• positive regulation of gene expression• BMP signaling pathway• cardiac muscle cell differentiation• cell development• regulation of receptor activity• negative regulation of gene expression• response to bacterium• regulation of apoptotic process• regulation of MAPK cascade UniProt P12643 Bản thể genChức năng phân tửThành phần tế bàoQuá trình sinh học Bản thể genChức năng phân tử• receptor binding• cytokine activity• co-receptor binding• phosphatase activator activity• growth factor activity• BMP receptor binding• GO:0001948 protein binding• retinol dehydrogenase activity• SMAD binding• protein heterodimerization activity• transforming growth factor beta receptor bindingThành phần tế bào• extracellular region• cell surface• BMP receptor complex• extracellular• intracellular membrane-bounded organelleQuá trình sinh học• skeletal system development• positive regulation of Wnt signaling pathway by BMP signaling pathway• positive regulation of protein phosphorylation• mesenchyme development• negative regulation of cell cycle• odontogenesis of dentin-containing tooth• telencephalon regionalization• protein phosphorylation• atrioventricular valve morphogenesis• proteoglycan metabolic process• mesenchymal cell differentiation• pericardium development• positive regulation of ERK1 and ERK2 cascade• BMP signaling pathway involved in heart induction• animal organ morphogenesis• inner ear development• cardiocyte differentiation• negative regulation of canonical Wnt signaling pathway• negative regulation of cell proliferation• positive regulation of p38MAPK cascade• pathway-restricted SMAD protein phosphorylation• cell fate commitment• regulation of transcription, DNA-templated• SMAD protein signal transduction• ossification• in utero embryonic development• mesenchymal cell proliferation involved in ureteric bud development• regulation of odontogenesis of dentin-containing tooth• positive regulation of transcription, DNA-templated• positive regulation of Wnt signaling pathway• heart development• telencephalon development• branching involved in ureteric bud morphogenesis• negative regulation of Wnt signaling pathway involved in heart development• cartilage development• bone mineralization involved in bone maturation• positive regulation of cartilage development• positive regulation of neuron differentiation• positive regulation of cell differentiation• thyroid-stimulating hormone-secreting cell differentiation• inflammatory response• positive regulation of fat cell differentiation• negative regulation of steroid biosynthetic process• positive regulation of MAPK cascade• Notch signaling pathway• bone mineralization• Biệt hóa tế bào• chondrocyte differentiation• corticotropin hormone secreting cell differentiation• positive regulation of astrocyte differentiation• positive regulation of bone mineralization• cellular response to organic cyclic compound• positive regulation of ossification• negative regulation of transcription from RNA polymerase II promoter• positive regulation of epithelial to mesenchymal transition• positive regulation of phosphatase activity• negative regulation of calcium-independent cell-cell adhesion• positive regulation of osteoblast differentiation• activation of MAPK activity• protein destabilization• embryonic heart tube anterior/posterior pattern specification• osteoblast differentiation• epithelial to mesenchymal transition• positive regulation of protein binding• negative regulation of transcription, DNA-templated• positive regulation of odontogenesis• positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus• negative regulation of aldosterone biosynthetic process• positive regulation of osteoblast proliferation• response to hypoxia• positive regulation of endothelial cell proliferation• positive regulation of cell migration• negative regulation of cortisol biosynthetic process• cell-cell signaling• positive regulation of pathway-restricted SMAD protein phosphorylation• cellular response to growth factor stimulus• cellular response to BMP stimulus• cardiac muscle tissue morphogenesis• endocardial cushion morphogenesis• multicellular organism development• negative regulation of cardiac muscle cell differentiation• positive regulation of apoptotic process• negative regulation of insulin-like growth factor receptor signaling pathway• oxidation-reduction process• positive regulation of transcription from RNA polymerase II promoter• cardiac epithelial to mesenchymal transition• positive regulation of pri-miRNA transcription from RNA polymerase II promoter• positive regulation of gene expression• BMP signaling pathway• cardiac muscle cell differentiation• cell development• regulation of receptor activity• negative regulation of gene expression• response to bacterium• regulation of apoptotic process• regulation of MAPK cascadeNguồn: Amigo / QuickGO Kết thúc 6,780,246 bp[1] RefSeq (protein) NP_001191 Loài Người Chức năng phân tử • receptor binding• cytokine activity• co-receptor binding• phosphatase activator activity• growth factor activity• BMP receptor binding• GO:0001948 protein binding• retinol dehydrogenase activity• SMAD binding• protein heterodimerization activity• transforming growth factor beta receptor binding RefSeq (mRNA) NM_001200 Danh pháp BMP2, BDA2, BMP2A, bone morphogenetic protein 2, SSFSC PubMed [2] ID ngoài OMIM: 112261 HomoloGene: 926 GeneCards: BMP2 NST Nhiễm sắc thể 20 (người)[1] PDB Tìm trên Human UniProt: PDBe RCSB Thành phần tế bào • extracellular region• cell surface• BMP receptor complex• extracellular• intracellular membrane-bounded organelle Danh sách mã id PDB Danh sách mã id PDB1ES7, 1REU, 1REW, 2GOO, 2H62, 2H64, 2QJ9, 2QJA, 2QJB, 3BK3, 3BMP, 4MID, 4N1D, 4UHY, 4UHZ, 4UI0, 4UI1, 4UI2 Vị trí gen (Người)NSTBăngBắt đầuKết thúc Vị trí gen (Người)NSTNhiễm sắc thể 20 (người)[1]Băng20p12.3Bắt đầu6,767,686 bp[1]Kết thúc6,780,246 bp[1] BăngBắt đầu 20p12.3 Ensembl ENSG00000125845 Vị trí gen (UCSC) Chr 20: 6.77 – 6.78 Mb Entrez 650 Cấu trúc được biết đếnPDBDanh sách mã id PDB Cấu trúc được biết đếnPDBTìm trên Human UniProt: PDBe RCSB Danh sách mã id PDB1ES7, 1REU, 1REW, 2GOO, 2H62, 2H64, 2QJ9, 2QJA, 2QJB, 3BK3, 3BMP, 4MID, 4N1D, 4UHY, 4UHZ, 4UI0, 4UI1, 4UI2
Thực đơn Protein tạo hình xương 2 Chức năng Tham khảo Đọc thêm Sử dụng lâm sàng và biến chứng Liên kết ngoài Tương tác
Liên quan Protein Protein liên kết hộp TATA Protein màng Protein xuyên màng Protein kinase A Protein thủy phân Protein tạo hình xương 7 Protein (dinh dưỡng) Protein ribosome Protein ribosome 40S S19
Tài liệu tham khảo WikiPedia: Protein tạo hình xương 2 http://med.stanford.edu/ism/2011/june/carragee-spi... http://www.hh.um.es/Abstracts/Vol_17/17_3/17_3_877... //www.ncbi.nlm.nih.gov/pmc/articles/PMC14828 //www.ncbi.nlm.nih.gov/pmc/articles/PMC313944 //www.ncbi.nlm.nih.gov/pubmed/10692589 //www.ncbi.nlm.nih.gov/pubmed/10712517 //www.ncbi.nlm.nih.gov/pubmed/10880444 //www.ncbi.nlm.nih.gov/pubmed/11263668 //www.ncbi.nlm.nih.gov/pubmed/12168799 //www.ncbi.nlm.nih.gov/pubmed/14623404
